What are the Unsolved Problems of Neuroscience?

In an interesting short paper just published in Trends in Cognitive Science, Caltech neuroscientist Ralph Adolphs offers his thoughts on The Unsolved Problems of Neuroscience.

Here’s Adolphs’ list of the top 23 questions (including 3 “meta” issues), which, he says, was inspired by Hilbert’s famous set of 23 mathematical problems:
Problems that are solved, or soon will be:
I. How do single neurons compute?
II. What is the connectome of a small nervous system, like that of Caenorhabi

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