Ketamine and Depression: A Breakthrough?

In recent years there has been great research interest in ketamine as an antidepressant. Ketamine, a drug better-known for its use as an anaesthetic (and a recreational drug in lower doses) is claimed to have powerful, rapid-acting antidepressant effects, even in depressed patients who have not responded to more conventional drugs. However, its mechanism of action remains unclear.

Now, in a major new Nature paper, Baltimore researchers Panos Zanos and colleagues say that ketamine itself is

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